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- AMPK Activator
- 90 vegetarian capsules
- Item Catalog Number: 01907
AMPK is an enzyme that serves as the body's master regulating switch. It inhibits multiple damaging factors by revitalizing aging cells.1
Found in every cell,2,3 AMPK promotes longevity factors that have been shown to extend life span in numerous organisms.1,4 Increasing AMPK signaling "turns off" many damaging effects of aging, thus enabling cells to return to their youthful vitality.5
Life Extension® scientists have compiled years of research to create AMPK Activator, a specialized dual-extract formulation that supports AMPK activation for health optimization. This natural formula supports AMPK enzymatic activities required to safely support a more youthful cellular environment.
Importance of AMPKGreater AMPK (adenosine monophosphate-activated protein kinase) activation has been shown to help target damaging factors of aging.5 Studies show increased AMPK activity supports reduced fat storage,6 new mitochondria production,7and the promotion of healthy blood glucose and lipids already within normal range.4
Gynostemma PentaphyllumAn extract of the plant Gynostemma pentaphyllum was traditionally used in Asian medicine to promote longevity and scientists now know why--G. pentaphyllum promotes AMPK activation.8-10 In one of many studies showing a wide variety of benefits, researchers documented a 1-inch reduction in abdominal circumference in overweight individuals who took 450 mg daily of G. pentaphyllum extract for 12 weeks.11
Trans-TilirosideTrans-tiliroside, extracted from plants such as rose hips, also boosts AMPK activation, but triggers different downstream metabolic benefits than G. pentaphyllum.12-14 Among its many benefits, a low equivalent dose of 56 mg daily trans-tiliroside has been shown by researchers in preclinical studies to promote healthy blood glucose levels and body weight already within normal range.15
Anti-Aging Discovery that Cannot be OverlookedScientists uncovered the cell-energizing effect of AMPK in the 1970s. Since then, an exponential volume of data (over 7,500 published studies) documents the critical role that activated AMPK plays in maintaining life-sustaining cellular functions.
Those seeking to meaningfully extend their healthy life span should ensure they optimally activate their cellular AMPK. The reason this is so important is that in response to aging, excess calorie consumption, and/or low levels of physical activity, AMPK activity markedly declines.
A targeted way of reversing cellular depletion of this critical enzyme is to take the new AMPK Activator formula that comprises a dual-extract, plant-based formulation.
References
1. J Mol Med (Berl). 2011 Jul;89(7):667-76.
2. J Proteome Res. 2011 Apr 1;10(4):1690-7.
3. Circ Res. 2007 Feb 16;100(3):328-41.
4. Physiol Rev. 2009 89:1025–78.
5. Age (Dordr). 2014 Apr;36(2):641-63.
6. Clin Sci (Lond). 2013 Apr;124(8):491-507.
7. Proc Natl Acad Sci USA. 2002 Dec 10;99 (25):15983-7.
8. Bioorg Med Chem. 2011 Nov 1;19(21):6254-60.
9. Carbohydr Polym. 2012 Jul 1;89(3):942-7.
10. Biotechnol Lett. 2012 Sep;34(9):1607-16.
11. Obesity (Silver Spring). 2014 Jan;22(1):63-71.
12. Diabetes Res Clin Pract. 2011 May;92(2):e41-6.
13. Prev Nutr Food Sci. 2013 Jun;18(2):85-91.
14. J Nutr Biochem. 2012 Jul;23(7):768-76.
15. Bioorg Med Chem Lett. 2007;17(11):3059-64.
Supplement FactsServing Size 1 vegetarian capsule
Amount Per ServingActivAMP™ Gynostemma pentaphyllum extract (leaf)
150 mg
Rose hip extract [from dog rose (Rosa canina) (stem and leaf) std. to 5% trans-tiliroside (18.6 mg)]
373 mg
Other ingredients: vegetable cellulose (capsule), microcrystalline cellulose, tapioca starch, dextrin, ascorbyl palmitate, silica.
Non-GMO
ActivAMP™ is a trademark of Gencor.
Dosage and Use
- Take two (2) capsules (servings) with the first meal of the day and one (1) capsule (serving) with the second meal, or as recommended by a healthcare practitioner.
- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.