If you don't take care of your health - Who will?
Information on chronic disease how you might avoid them or reduce their impact
The following is provided by our Product Partner, Life Extension
Maylin Rodriguez-Paez, RN
It’s no coincidence that our name is Life Extension. Our sole purpose is to find ways to extend the healthy, human life span. And if you haven’t noticed yet, it really is our passion.
Of course, eating healthy and exercising are top priorities for any anti-aging program, but we think there’s more to the story than that.
Nature has given us additional “tools” in the form of antioxidants to help fight and even reverse aging. As such, it’s no surprise that exploring them in depth has been a major focal point of ours for decades.
So what are our “favorite” antioxidants for helping to slow the aging process after all of these years? Below, we’ll dive into three key supplements that may just deserve this highly-coveted status.
First Things First: Why Do we Age?Scientists aren’t exactly sure why we age, but multiple theories exist. One is the mitochondrial theory of aging. It states that the root cause of aging is oxidative stress to the mitochondria.
Mitochondria are the energy powerhouses of cells. Their job is to produce ATP (adenosine tri-phosphate), the energy currency of all cells. During production, however, free radicals are formed, an effect that damages mitochondria.
Through time, the mitochondria in your cells “take a beating” … their numbers eventually decrease, making you vulnerable to the effects of aging and disease. In fact, many diseases we associate with growing old (type II diabetes, Alzheimer’s, heart failure, and cancer1-5) are actually associated with mitochondrial dysfunction.
Luckily, certain nutrients can help.
CoQ10 Extends the Lives of AnimalsA house can’t run without energy, and neither can your body. That’s where CoQ10 comes into play. This vitamin-like substance helps the mitochondria “burn fuel” more effectively. It helps the energy transfer needed to make ATP. Without it, mitochondria become dysfunctional and aging accelerates.6
CoQ10 supplementation has been shown to extend the lives of different species. It lowers the oxidative stress inflicted on mitochondria. In one study, mice given CoQ10 lived 11.7% years longer,7 which is approximately 9 human extra years based on today’s life expectancy (78.5 years).
PQQ Helps Grow New MitochondriaPQQ is an antioxidant found in all plants. Animals need it for growth and reproduction. Like CoQ10, it helps the energy transfer process of mitochondria. But there’s one thing that makes it very unique and important: it increases the number of mitochondria in cells.8
Studies show, animals deprived of PQQ present stunted growth, decreased immune function, and fewer mitochondria in their tissue.9-11 When given PQQ, these effects are reversed.
PQQ is also one of the strongest antioxidants around, hands down. It’s actually about 5,000 times more powerful at withstanding oxidation than vitamin C.12
Carnitine Decreases Death RatesCarnitine is nearly found in all cells in the human body. It transports fats to the mitochondria where they’re “burned” for energy. With age, carnitine levels drop significantly leaving the mitochondria vulnerable to destruction.
Carnitine guards nerve cells against damage. A particular form called acetyl-L-carnitine (ALCAR) prevents the accumulation of amyloid plaque, an abnormal protein implicated in Alzheimer’s disease.13 It also enhances cognition. In different studies, elderly people taking ALCAR show improved memory and mental status scores.14-15
Your heart needs carnitine to function optimally. Decreased levels weaken the heart, compromising function. In one study, heart attack survivors taking carnitine showed decreased blood pressure levels, improved lipids, and a decreased death rate compared to a placebo group (12.5% versus 1.2%).16
The Bottom LineAging starts at the cellular level — what we see on the outside is only a very small part of the picture. Powerful antioxidants such as Carnitine, PQQ, and CoQ10 have proven to be strong allies for optimizing cellular energy, which may very well be the key to living a long and healthy life.
Are you supplementing with these three antioxidants? We certainly are!
By Susan Goldschein
MIT researchers discovered and patented magnesium L-threonate based on its unique ability to boost brainlevels of magnesium.
Rapid absorption and ability to enter the brain enables this magnesium to structurally reverse certain aspects of brain aging.1-4
A recent human study demonstrates the benefits of magnesium L-threonate in adults with cognitive dysfunction, sleep disorders, and anxiety.1
The most startling finding is a reversal of more than nine years in clinical measures of brain aging in people who supplemented with magnesium L-threonate.
Magnesium L-threonate (MgT) was developed at the Massachusetts Institute of Technology.2
MgT (pronounced “Mag T”) is special because of the way it boosts brain magnesium levels when taken orally. This effect is due to its unique ability to cross the blood-brain barrier.2
Research has shown that once MgT gets into the brain, it increases the density of synapses, which are the communication connections between brain cells.1
This is critical because loss of synaptic density is associated with brain shrinkage and cognitive decline.5,6
Published Human Data
Scientists at three independent institutions carried out a randomized, double-blind, placebo-controlled clinical trial of MgT in older adults with cognitive impairment.1
To participate in the study, candidates had to be between the ages of 50 and 70, and have self-reported complaints of memory problems, sleep disorders, and anxiety.1
This study was based on the premise that sleep and anxiety disorders correlate with perceived memory loss.7 Those who report mild cognitive impairment and who also have sleep and anxiety disorders are more likely to develop Alzheimer’s.1,8-11
In this multi-center study, participants were randomly assigned to receive placebo or magnesium L-threonate in the dose of 1,500-2,000 mg each day (depending on body weight) for 12 weeks.
Baseline cognitive testing commenced before people started taking MgT or placebo. These cognitive tests were then repeated at six-week and 12-week points.1
The following four separate tests were used to evaluate cognitive function:
• Executive function
• Working memory
• Episodic memory (ability to recall fleeting events)
Findings from this study revealed:
1. MgT improved body magnesium status. After 12 weeks researchers found significant increases in red blood-cell concentration and in urinary excretion of magnesium in the treated group.1 Increased urinary excretion indicates that large amounts of magnesium have been absorbed, while increased levels in red blood cells show high circulating levels of magnesium in the body.
2. MgT improved cognitive abilities. Using a test of visual attention and task switching, researchers saw significant increases in performance speed for executive function and cognitive processing. These benefits appeared as early as week six on some of the tests.1 Most tellingly, the overall composite scores for all tests of the MgT-supplemented group increased significantly compared with baseline scores and with those of placebo recipients at weeks six and 12.
3. MgT reduced fluctuation in cognitive ability. When cognitive functions are worse on some days than others, it is a warning sign of developing mild cognitive impairment.12,13 In the present study, while placebo recipients showed considerable fluctuation in their cognitive scores, those in the MgT group had primarily positive changes.1
4. MgT reversed clinical measures of brain aging. This is a significant finding, which we’ll explain in more detail in the next section.
Someone striving to enjoy the later years of life by being healthy, happy and wise.
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